To solve this rebus, it is simply necessary to add and subtract the given words and letters, with spaces representing the word breaks.
W + HAT = WHAT
C + LAPIS (From Minecraft) – CLAP = IS
FIRE + WEST – EWE (A female sheep) = FIRST
F + SINGER – S = FINGER
JON (Arbuckle, from Garfield)-J = ON
AT – T = A
H + AND = HAND
This gives the clue phrase What is first finger on a hand?, which is of course the THUMB.